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Hawthorne, D. J. & Via, S. 2001 Genetic linkage of ecological specialization and reproductive isolation in pea aphids. Nature 412, 904907. Laurie, C. C., True, J. R., Liu, J. & Mercer, J. M. 1997 An introgression analysis of quantitative trait loci that contribute to a morphological difference between Drosophila simulans and D. mauritiana. Genetics 145, 339348. Lewontin, R. C. & Birch, L. C. 1966 Hybridization as a source of variation for adaptation to new environments. Evolution 20, 315336. Lexer, C., Welch, M., Durphy, J. L. & Rieseberg, L. H. 2003a Natural selection for salt tolerance QTL in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a homoploid hybrid species. Mol. Ecol. In the press. ; Lexer, C., Welch, M., Raymond, O. & Rieseberg, L. H. 2003b The origins of ecological divergence in Helianthus paradoxus Asteraceae ; : selection on transgressive characters in a novel hybrid habitat. Evolution In the press. ; Liu, B. H. 1998 Statistical genomics. Boca Raton, FL: CRC Press. Noor, M. A. F., Cunningham, A. L. & Larkin, J. C. 2001 Consequences of recombination rate variation on quantitative trait locus mapping studies: simulations based on the Drosophila melanogaster genome. Genetics 159, 581 588. Orr, H. A. 1998 Testing natural selection vs. genetic drift in phenotypic evolution using quantitative trait locus data. Genetics 149, 20992104. Otto, S. P. & Whitton, J. 2000 Polyploid incidence and evolution. A. Rev. Genet. 34, 401437. Rieseberg, L. H. 1997 Hybrid origins of plant species. A. Rev. Ecol. Syst. 28, 359389. Rieseberg, L. H. & Ellstrand, N. C. 1993 What can morphological and molecular markers tell us about plant hybridization? Crit. Rev. Pl. Sci. 12, 213241. Rieseberg, L. H., Archer, M. A. & Wayne, R. K. 1999 Transgressive segregation, adaptation, and speciation. Heredity 83, 363372. Rieseberg, L. H., Widmer, A., Arntz, M. A. & Burke, J. M. 2002 Directional selection is the primary cause of phenotypic diversification. Proc. Natl Acad. Sci. USA 99, 12 24212 Rosenthal, D. M., Schwarzbach, A. E., Donovan, L. A., Raymond, O. & Rieseberg, L. H. 2002 Phenotypic differentiation between three ancient hybrid taxa and their parental species. Int. J. Pl. Sci. 162, 387398. Sokal, R. R. & Rohlf, F. J. 1995 Biometry, 3rd edn. New York: Freeman. Stebbins, G. L. 1959 The role of hybridization in evolution. Proc. Am. Phil. Soc. 103, 231251. Tanksley, S. D. & McCouch, S. R. 1997 Seed banks and molecular maps: unlocking genetic potential from the wild. Science 277, 10631066. True, J. R., Jianjun, L., Lynn, F. S., Zeng, Z. B. & Laurie, C. C. 1997 Quantitative genetic analysis of divergence in male secondary sexual traits between Drosophila simulans and Drosophila mauritiana. Evolution 51, 816832. Welch, M. E. & Rieseberg, L. H. 2002 Habitat divergence between a homoploid hybrid sunflower species, Helianthus paradoxus Asteraceae ; , and its progenitors. Am. J. Bot. 89, 472478. Wolf, D. E., Takebayashi, N. & Rieseberg, L. H. 2001 Predicting the risk of extinction through hybridization. Conserv. Biol. 15, 10391053.

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At the start of each block, subjects were cued for 2 secs ; to attend selectively to either the two vertically-arranged or two horizontally-arranged positions, while the alternative two locations were to be ignored throughout the block. Thus attention was directed on the basis of spatial location, rather than on the basis of stimulus type per se face versus house ; . In total, there were four blocks of forty trials each. Each trial consisted of a central fixation cross 1 sec ; followed by the four-picture display for 250 ms. Subjects were required to indicate, as accurately and rapidly as possible, whether the two stimuli at task-relevant locations were the same or different, by either of two possible key presses with the right hand. Reaction time RT ; and accuracy were recorded. The median intertrial interval was 2.5 secs range: 1.5 14.4 secs.

UCSF Fresno educates one-third of Central Valley physicians currently practicing in one of seven specialties. UC research proved blueberries could be grown in the Valley, contrary to popular belief. UC President Robert C. Dynes shared and learned about many of UC's connections and contributions to the San Joaquin Valley when he visited the region in April for the second time in six months as part of his inaugural tour. Dynes became the 18th president of the 10-campus University of California system in October, and rather than holding a traditional academic inauguration, he decided to visit communities. He endothelial cell production of nitric oxide NO ; accounts for endothelium-dependent vasodilatation.1 Despite a growing understanding of the mechanisms by which NO is released from the endothelium, the precise molecular mechanisms by which NO relaxes vascular smooth muscle are not fully understood. A variety of mechanisms have been proposed by which NO participates in the regulation of smooth muscle free [Ca2 ]i, which is the primary determinant of contractile tone.2 Among them, several different mechanisms for NO-induced inhibition of Ca2 influx through L-type Ca2 channels have been proposed, including their inhibition by cGMP-dependent mechanisms3 or by membrane hyperpolarization due to direct 4 or indirect cGMPdependent5, 6 activation of Ca2 -dependent K channels. NO also has been proposed to reduce [Ca2 ]i by inhibiting the agonist-induced release of Ca2 from intracellular stores7 or by increasing Ca2 removal from the cytoplasm by acceler.

Hart and colleagues hypothesize that the use of OAT merely unmasks intracerebral bleeding that would otherwise remain asymptomatic, especially in patients with underlying hypertension or cerebrovascular disease.20 A number of observations support this hypothesis. First, gradient-echo MRI indicates that microbleeds can be found even in neurologically normal individuals and are strongly associated with increased age and hypertension.21 Second, cerebral amyloid angiopathy is most commonly found in people over 65 years of age and is a major risk factor for SICH in the elderly. Both advancing age and cerebral amyloid angiopathy are also important contributory factors to lobar ICH in patients who are receiving OAT, 22, 23 suggesting that, in many cases, both SICH and OAT-ICH may have the same underlying cause. Third, data from the Stroke Prevention in Reversible Ischemia Trial SPIRIT ; and the European Atrial Fibrillation Trial EAFT ; indicate that patients with primary underlying cerebrovascular disease had a remarkably higher risk of OAT-ICH.24, 25 Moreover, studies suggest that the presence of white matter lesions, so-called "leukoaraiosis, " is an independent predictor of SICH.26 The underlying causes of SICH and OAT-ICH may therefore be the same, with OAT acting as an exacerbating factor. These considerations may also explain why the distribution of locations in the brain where OAT-ICH occurs is no different from that seen in patients with SICH.4, 13 Although the majority of OAT-ICH cases occur when a prothrombin time-international normalized ratio PT-INR ; is within the therapeutic range, higher intensities of anticoagulation clearly increase the risk of OAT-ICH, 4, 5, 17, suggesting.

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Coulthard P, Worthington H, Esposito M, van der Elst M, van Waes OJF This review should be cited as Coulthard P, Worthington H, Esposito M, van der Elst M, van Waes OJF, Tissue adhesives for closure of surgical incisions. Cochrane Review ; In: The Cochrane Library, Issue 2, 2004. Chichester, UK: John Wiley & Sons, Ltd. SYNOPSIS It is unclear whether tissue adhesives are more or less effective for closing surgical incisions than stitches or adhesive tape. Tissue adhesive maybe quicker and easier to use than stitches for closing surgical wounds, and there are no stitches to remove. This review compares tissue adhesive with stitches and adhesive tape. There were a few studies included and in one study the surgeon rated the cosmetic appearance higher for the incisions closed by the tissue adhesive however no other differences were found. ABSTRACT Background: Sutures, staples and adhesive tapes are the traditional methods of wound closure, whilst tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables meticulous closure, but sutures may induce tissue reactivity and they usually require removal. Tissue adhesives offer the advantages there are no sutures to remove later for the patient and no risk of needlestick injury to the surgeon. Tissue adhesives have been used primarily in emergency rooms but this review looks at the use of tissue adhesives in the operating room where surgeons are increasingly using these for the closure of surgical skin incisions. Objectives: To determine the relative effects of various tissue adhesives and conventional skin closure techniques on the healing of surgical wounds. Search strategy: The Cochrane Wounds Group Specialised Trials Register, The Cochrane Central Register of Controlled Trials CENTRAL ; , MEDLINE and EMBASE were searched. Bibliographies of review articles were checked for studies outside the handsearched journals and wound care product manufacturers were contacted. Selection criteria: Randomised controlled clinical trials only and adalimumab.
Rip Tide Window Cleaning, serving coast, canyons & valleys. 20 years experience spanning commercial to residential. Low rates, free estimates. All size jobs. Eco friendly, seniors discount, satisfaction guaranteed. 818-347-5742. 0615 I can see clearly now! Prompt, professional, punctual. Call now for a free estimate. 12 years cleaning windows in Malibu. Econo Clean. Your satisfaction is guaranteed. 310-456-8707. Serum LH and FSH concentrations were determined by microparticle enzyme immunoassay using an automated Abbott AxSYM system Abbott Laboratories, Chicago, IL ; . The Second International Reference Preparation was used as the reference standard. The assay sensitivity for both LH and FSH is 1.6 mIU mL. The intraassay coefficients of variation CVs ; for LH and FSH are less than 7% and less than 6%, respectively, with interassay CVs for both hormones of less than 7.4%. Serum T concentrations were measured using the Coat-A-Count RIA kit Diagnostics Products, Los Angeles, CA ; , which has intra- and interassay CVs of less than 10%. E2 was measured by the Abbott AxSYM system Chicago, IL ; , which has an analytical sensitivity of 10 pg pmol L ; , an intraassay CV of less than 6.4%, and an interassay CV of less than 10.6%. Neither ketoconazole nor dexamethasone cross-reacted in the E2 assay; at a concentration of 10 mg mL the percent interference by anastrozole was 0.001. In a subset of three patients from both protocols, E2 was also measured in a more sensitive RIA using hexane ethylacetate extraction and LH-20 chromatography Endocrine Sciences, Inc., Calabasas Hills, CA ; . The Endocrine Sciences, Inc., E2 assay has a sensitivity of 5 pg pmol L ; and, based on a male serum pool, has an intraassay CV of 4.9% and an interassay CV of 15%. Inhibin B was measured using a commercially available, double antibody, enzymelinked immunosorbent assay Serotec, Oxford, UK ; as previously described 30 ; . In our use, the clinical detection limit of this assay is 50 pg mL, with a CV of within plate and 1518% between plates and adefovir.

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Support for this work was provided by the Canadian Cochrane Network and by the Department of Community Health Sciences at the University of Manitoba. Thanks to Mary Cheang, MSc, for statistical assistance. References 1. Klein JO, Teele DW, Rosner BA, et al. Epidemiology of acute otitis media in Boston children from birth to seven years of age. In: Lim DJ, Bluestone CD, Klein JO, Nelson JD, eds. Recent Advances in Otitis Media With Effusion: Proceedings of the Fourth International Symposium. Toronto, Canada: BC Decker; 1988: 6-8. 2. Froom J, Culpepper L, Grob P, et al. Diagnosis and antibiotic treatment of acute otitis media. BMJ. 1990; 300: 582-586. McCaig LF, Hughes JM. Trends in antimicrobial drug prescribing among office-based physicians. JAMA. 1995; 273: 214-219. Stool SE, Field MJ. The impact of otitis media. Pediatr Infect Dis J. 1989; 8: S11-S14. 5. Berman S. Otitis media in developing countries. Pediatrics. 1995; 96: 126-131. Mygind N, Meistrup-Larsen KI, Thomsen J, Thomsem VF, Josefsson K, Sorensen H. Penicillin in acute otitis media. Clin Otolaryngol. 1981; 6: 5-13. Burke P, Bain J, Robinson D, Dunleavey J. Acute red ear in children. BMJ. 1991; 303: 558-562. Van Buchem FL, Dunk JHM, Van't Hof MA. Therapy of acute otitis media: myringotomy, antibiotic or neither? Lancet. 1981; 2: 883-887. Rosenfeld RM, Vertrees JE, Carr J, et al. Clinical efficacy of antimicrobial drugs for acute otitis media. J Pediatr. 1994; 124: 355-367. Del Mar C, Glazziou P, Hayem M. Are antibiotics indicated as initial treatment for children with acute otitis media. BMJ. 1997; 314: 1526-1529. Cohen ML. Epidemiology of drug resistance. Science. 1992; 257: 1050-1055. Murray BE. Can antibiotic resistance be controlled? N Engl J Med. 1994; 330: 1229-1230. Paradise JL. Managing otitis media: a time for change. Pediatrics. 1995; 96: 712-715. Paradise JL. Short-course antimicrobial treatment for acute otitis media: not best for infants and young children. JAMA. 1997; 278: 1640-1642. Pichichero ME, Cohen R. Shortened course of antibiotic therapy for acute otitis media, sinusitis, and tonsillopharyngitis. Pediatr Infect Dis J. 1997; 16: 680-695 and adriamycin.
Tequant de I'Aorts--Flament-Durand J Department of Neuropathology, Rue aux Laines 97, B-1000, Bruxelles, Belgique ; , Ebinger G, Retif J --Ada Neurol Belgium ; 71: 475-485, 1971 Symptoms and signs of a transverse spinal cord lesion developed suddenly in a 67-year-old man. Dissecting aneurysm of the aorta was found to be the cause; microscopic examination of the aorta revealed atherosclerosis and abnormalities of the media. We will receive additional cash payments from intermune in march 2001, and royalties on actimmune sales after december 31, 200 f-24 70 1 contingency boehringer ingelheim manufactures relaxin for us for clinical uses under a long-term contract and agenerase.

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DEBATE 12 53. At its eighth meeting, the Commission examined items 5.10 "Establishment of an international centre for water hazard and risk management ICHARM ; in Tsukuba, Japan, under the auspices of UNESCO", 5.16 "Proposal for the establishment of an IHP-HELP centre for water law, policy and science at the University of Dundee, United Kingdom" and 5.32 "Proposed establishment of the Regional Water Centre for Arid and Semi-Arid Zones of Latin America and the Caribbean CAZALAC ; under the auspices of UNESCO, in La Serena Chile ; ". The representatives of 20 Member States took the floor on these items. Item 5.10 Proposed establishment of the international centre for water hazard and risk management ICHARM ; in Tsukuba, Japan, under the auspices of UNESCO. Licensed products in addition to the royalties mentioned above, we also receive royalties on the following products from the following companies: product trademark company human growth hormone humatrope eli lilly and company hepatitis b vaccine recombivax merck and company, inc hepatitis b vaccine engerix-b glaxosmithkline plc factor viii kogenate helixate bayer corporation bovine growth hormone posilac monsanto company interferon gamma-1b actimmune see above ; intermune soluble tnf receptor enbrel immunex corporation infliximab remicade celltech pharmaceuticals plc abciximab reopro centocor, inc interferon beta-1b betaseron berlex laboratories, inc interferon alfacon-1 infergen amgen, inc bosentan tracleer actelion ltd products in development our product development efforts, including those of our collaborative partners, cover a wide range of medical conditions, including cancer, respiratory disorders, cardiovascular diseases, endocrine disorders, and inflammatory and immune problems and aggrenox. Verginis P , Stanford MM and Carayanniotis G. Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis. J. Immunol. 2002; 169: 5332-7. MM.1R cells in a dose-dependent fashion, albeit at higher concentrations compared to the drug sensitive cell lines. Figure 1C ; Dex resistant MM1.R cells were most sensitive, suggesting a lack of cross-resistance to combined therapy versus dexamethasone and alefacept.
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