Questions 1-10: Please choose the best answer. 1. The following statements concerning treatment of psoriasis by etanercept are correct except: a. Comparing with other biological agents, the onset of clinical improvement is slow. b Etanercept has a similar mode of action as infliximab. c. It is approved by FDA for the treatment of moderate to severe chronic plaque psoriasis patients who are candidates for systemic therapy or phototherapy. d. The main side effects are upper respiratory tract infection and injection site reactions. e. Induction of antinuclear antibodies and anti-double stranded DNA were reported after treatment with etanercept. 2. The following are relevant side effects of alefacept except: a. Pharyngitis b. Headache c. Rhinitis d. Lymphoctyosis e. Injection site reaction and transient chill during the first day of treatment 3. FDA recommends monitoring of the following parameter s ; during treatment with efalizumab: a. Chest X ray b. White cell count c. Tuberculin test d. Platelet count e. All of the above 4. The following are correct modes of action of the biological agents designed to block the specific steps in the pathogenetic pathway of psoriasis except: a. Alefacept inhibits T cell activation by blocking the co-stimulatory signal 2. b. Etanercept binds soluble and bound tumour necrosis factor TNF ; alpha and blocks its action. c . Alefacept eliminates activated T cells selectively. d. Efalizumab induces immune deviation from TH1 to TH2 differentiation in the activated T cell. e. Infliximab inhibits the action of cytokines, especially tumour necrosis factor TNF ; alpha. 5 The following is are disadvantage of treatment with infliximab in psoriasis: a. High treatment cost. b. Reactivation of latent tuberculosis. c. Potential serious anaphylaxis during drug administration. d. a and c. e. All of the above 6. The following statements concerning the use of alefacept in the treatment of psoriasis are correct except: a. Comparing with other biologics, the remission induced by alefacept is transient and significant clinical relapse is one of the major disadvantages. b. It was already approved by FDA of USA for the treatment of moderate to severe plaque psoriasis in adult patients. c Alefacept is a recombinant human LFA-3 IgG1 dimeric fusion protein. d. Alefacept is administered weekly either by intramuscular or by intravenous bolus injection. e. The best clinical efficacy usually occurs few weeks after completing the course of treatment. 7. The following biological agent s ; can be administered at home by trained patients themselves: a. Efalizumab b. Infliximab c. Etanercept d. a and c e. all of the above 8. The following statements concerning the use of efalizumab in the treatment of psoriasis are correct except: a. The usual dosage is 1mg kg weekly for a course of 12 week. b Long term treatment of efalizumab up to 60 weeks was proven to be safe and well tolerated. c. Comparing with other biologics, remission in the responders was long-lasting and a significant number of patients still remained clear even after stopping treatment. d. It is usually given by subcutaneous injection. e. Additional clinical improvement could be achieved by prolonged treatment beyond 12 weeks with enhanced clinical efficacy. 9. In treating patients with psoriatic arthropathy complicating extensive stable plaque psoriasis, the following biological agent is an FDA approved treatment option: a. Alefacept b. Efalizumab c. Infliximab d. Etanercept e. None of the above 10. Which of the following statement s ; concerning the use of infliximab in the treatment of psoriasis is are correct: a. It is administered subcutaneously. b. It is given in 50mg twice a week for a course of 12 week. c. It is approved by FDA for the treatment of Crohn's disease and rheumatoid arthritis. d. No laboratory monitoring is required by FDA e. All of the above.
Reactions with a 1% to 10% frequency included chills 6%, primarily during iv administration ; , dizziness, pruritus, nausea, myalgia, pharyngitis, cough, malignancies 1% vs 2% in placebo ; , antibodies to alefacept 3%, significance unknown ; , and infections 1% to 2% requiring hospitalization.
`Neutrality' implies non-participation by a state in a war between other states, thus, the neutral state abstains from involvement in a particular war and treats both belligerents equally.5 In the context of Cold War, the United States US ; and the Soviet Union both attempted to spread their spheres of influence to create blocs which support their position in the war, at least ideologically. A neutral state thus means a state which treats both super powers equally and non-alignment with neither of the two military blocs lead by one super power. The ASEAN foreign ministers adopted the neutrality concept in 1971 as the Kuala Lumpur Declaration, and agreed to.
132. Clinical Diagnosis in the Evaluation of Chronic Pelvic Pain, Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Chicago IL, June 133. Alternatives to Hysterectomy for Uterine Fibroids, Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Chicago IL, June 134. SERMs: Are They the Answer for Menopause? Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Chicago IL, June 135. Clinical Diagnosis in the Evaluation of Chronic Pelvic Pain. Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Charleston SC, June 136. Extending the Safety and Efficacy of GnRH Agonists in Gynecology: Steroidal and Nonsteroidal Add-Back Therapy. Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Charleston SC, June 137. Testing a Test: How Do We Know If a Screen Is Reliable? New Methods in Screening for Prenatal Risks, American College of Obstetricians and Gynecologists, Toronto Ontario, August 138. Principles of Teratology. New Methods in Screening for Prenatal Risks, American College of Obstetricians and Gynecologists, Toronto Ontario, August 139. Evaluating Pregnancy Exposures for Risk. New Methods in Screening for Prenatal Risks, American College of Obstetricians and Gynecologists, Toronto Ontario, August 140. Doing Tests, Not Doing tests: Where is the Liability? New Methods in Screening for Prenatal Risks, American College of Obstetricians and Gynecologists, Toronto Ontario, August 141. Chronic Pelvic Pain. Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Minneapolis MN, August 142. The Use of Add-Back Therapy in Treating Common Gynecologic Disorders. Making a Difference: New Strategies for Difficult Gynecologic Disorders, Medical Education Collaborative, Minneapolis MN, August 143. Chronic Pelvic Pain. Grand Rounds, Department of Obstetrics and Gynecology, University Hospitals of Cleveland Case Western Reserve University ; , Cleveland OH, September 144. Osteoporosis: Is Estrogen Enough? The Estrogen Question, Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington DC, October 145. Hormone Therapies: Are There Alternatives That Work? The Estrogen Question, Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington DC, October 146. Drugs and Environmental Factors. Improving Birth Outcomes in Developing Countries Workshop, Institute of Medicine, Washinton DC, October 147. Chronic Pelvic Pain. Grand Rounds, Department of Obstetrics and Gynecology, Ohio State University, Columbus OH, October 148. Chronic Pelvic Pain. Grand Rounds, Department of Obstetrics and Gynecology, Johns HopkinsUniversity, Baltimore MD, October 149. Management of the Chronic Pelvic Pain Patient. Medical College of Ohio, Toledo OH, November 150. Medical and Surgical Alternatives for Uterine Fibroids. Grand Rounds, Department of Obstetrics and Gynecology, Olive View-UCLA Medical Center, Sylmar CA, December 151. Chronic Pelvic Pain. Grand Rounds, Department of Obstetrics and Gynecology, St Joseph's Hospital and Medical Center, Phoenix AZ, January 152. Add-back Hormone Replacement Therapy. Grand Rounds, Department of Obstetrics and Gynecology, Downstate Medical Center, Brooklyn NY, January.
1. Fedak PWM, Verma S, Weisel RD, Li RK. Cardiac remodeling and failure: from molecules to man part I ; . Cardiovasc Pathol. 2005; 14: 111. Spinale FG. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res. 2002; 90: 520 Fedak PWM, Altamentova SM, Weisel RD, Nili N, Ohno N, Verma S, Lee TY, Kiani C, Mickle DA, Strauss BH, Li RK. Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. J Physiol. 2003; 284: H626 H634. 4. Fedak PWM, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 2004; 110: 24012409. Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM. ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun. 2000; 278: 511515. Amour A, Knight CG, Webster A, Slocombe PM, Stephens PE, Knauper V, Docherty AJ, Murphy G. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Lett. 2000; 473: 275279. Amour A, Slocombe PM, Webster A, Butler M, Knight CG, Smith BJ, Stephens PE, Shelley C, Hutton M, Knauper V, Docherty AJ, Murphy G.
Sion of CYP3A mRNA Fig. 1B ; . The presence of dexamethasone did not detectably affect CYP3A basal expression although it had a slightly positive effect on the PB induction of CYP3A at all PB concentrations tested, and after 24 and 72 h of treatment data not shown ; . However, no effect was detected when compared with the cells cultured in the absence of dexamethasone and exposed to 2 mM for 48 h, a condition that gave the strongest induction Fig. 1A ; . This result, as well as the fact that no morphological changes were observed between cells treated or not with dexamethasone, led us to avoid the use of this molecule in subsequent experiments. Effect of Inhibitors and Activators of Protein Kinases Phosphatases on CYP3A mRNA Levels. Various agents known to affect different regulatory pathways were screened for their ability to influence the PB-mediated CYP3A induction. Genistein, a tyrosine kinase inhibitor, had no detectable effect on either the basal or PB-induced expression of CYP3A mRNA at the concentrations of 10 and 50 M data not shown ; . Staurosporine 100 and 200 nM ; , a broad spectrum serine threonine kinase inhibitor, had a positive dose-dependent effect on induced CYP3A expression increased to 226.1 35.4 and 302.0 43.4%, respectively ; whereas other broad spectrum kinase inhibitors, H7 and HA-1004 10 M ; , inhibited this induction decreased to 26.3 0.8 and 13.8 1.2%, respectively; Fig. 2A ; . At the concentration of 10 M, H7 known to inhibit PKA, PKC, and PKG, whereas HA-1004 only inhibits PKA and PKG. These latter results thus suggested the implication of PKA and or PKG in PB induction. The effect of staurosporine could have been consistent with the involvement of a PKCdependent pathway but this possibility was ruled out by testing a specific PKC inhibitor, Ro-31 8220 50 and 100 nM ; , which had no effect on either basal or induced CYP3A expression Fig. 2B ; . Similarly, other more specific serine threonine protein kinase inhibitors such as PD-98059 10 and 50 M ; , a mitogen-activated protein kinase kinase inhibitor, or LY-294002 5 and 10 M ; , a potent and specific phosphatidylinositol-3-kinase inhibitor had no effect either data not shown ; . None of these molecules had any detectable influence on basal expression of CYP3A mRNA. The same result was observed for okadaic acid: this serine threonine phosphatase inhibitor showed no effect on basal or PB-induced CYP3A mRNA levels at the concentrations tested 10 and 100 nM; data not shown ; . In all these cases, albumin mRNA level remained unaffected Fig. 2, A and B ; . In view of these results, we decided to more specifically analyze the involvement of PKA PKG pathways in controlling the effects of PB on CYP3A mRNA expression. A specific PKA PKG inhibitor, H89, produced a significant dose-dependent inhibition of induced CYP3A expression at the concentrations of 1 and 5 M decreased to 71.1 7.4 and 30.9 7.3%, respectively ; , but no effect on albumin mRNA level Fig. 2C ; . This observation, together with the as yet unexplained enhancement of CYP3A induction by PB upon staurosporine treatment, led us to verify what effect was elicited by specific activators and inhibitors of PKA or PKG. db-cAMP, an analog of cAMP that activates the PKA pathway, produced an important inhibition of CYP3A expression at the concentration of 10 M decreased to 18.5 4.4% ; , although this inhibition was less marked decreased to 74.1 8.6% ; when the concentration of this molecule was and aleve.
Lecithins" ; as active substance in traditional herbal medicinal products. The view of the HMPC in this matter is available in a newly published Q&A document on technical issues cf. section on `organisational matters' below ; . The following documents adopted at the 8-9 March 2006 HMPC for release for public consultation are for consultation in the joint CHMP CVMP Quality Working Party meeting scheduled for 22-24 May 2006: Draft `Guideline on the declaration of herbal substances preparations in finished herbal medicinal products traditional herbal medicinal products in the SPC' EMEA HMPC 287539 2005 ; Draft `Concept paper on the quality of combination herbal medicinal products' EMEA HMPC 58222 2006.
Day: Time: Contact: Location: Third Monday of each Month 7: 00 p.m. to 9: 00 p.m. Don Hunt, 217.789.2182, Ext. 111 Springfield Department of Public Health 1415 East Jefferson, Main Floor Conf. Room and almotriptan
Reversing the double-digit growth in PMPY costs seen over the last several years, the 2002 PMPY costs for dermatologicals rose by only 4.8 percent in 2002. An 8.8 percent increase in inflation overtook the 3.7 percent decline in utilization of these products. The generic fill rate in this class rose from 35.8 percent in 2001 to 40.4 percent in 2002. The FDA approved an application for Amevive alefacept ; for the treatment of psoriasis in adults. Amevive is an immunosuppressive agent injected either intravenously or intramuscularly once weekly in 12-week cycles.
Competing interests: um is a consultant for or has received travel grants or honorariums from biogenidec the manufacturer of alefacept ; , centocor the manufacturer of infliximab ; , essex schering plough, fujisawa, fumapharm, glaxosmithkline, hermal, leo pharmaceuticals, merz pharma, mö lnlycke healthcare, novartis, schering, serono the manufacturer of efalizumab ; , and wyeth the manufacturer of etanercept and alfuzosin
Alefacept induces activation of and intracellular signaling in in vitro IL-2-expanded NK cells that is dependent on CD2 and CD16 binding. We next considered that alefacept-mediated apoptosis of NK cells Fig. 2 ; may reflect activation-induced intracellular processes similar to the apoptosis of IL-2-activated NK cells stimulated by antiCD16 mAb 35 ; or anti-CD2 mAbs 36, 37 ; . Thus, we investigated whether alefacept has agonistic properties. NK cells were incubated with 10 g ml alefacept or control proteins for 20 h in the presence of IL-2 and then analyzed by flow cytometry for the expression of activation markers CD25, and CD95 Fas ; . The results show that incubation of NK cells with alefacept, anti-CD2 mAbs, or anti-CD16 mAb, but not CA139 or LT R IgG1, resulted in up-regulation of the expression of CD25 Fig. 2B, upper panel ; , but not CD95 Fig. 2B, lower panel ; , which is already highly expressed by these in vitro IL-2 expanded NK cells Fig. 2B, lower panel ; . Such an agonistic effect of alefacept on IL-2-expanded human T cells was not noted data not shown.
Mar 31, 2006 petition from drugs that offer alternative approaches to the treatment of inflammatory disease, including the t-cell modulators efalizumab and alefacept and and alimta.
Alefacept saleWhen analyzed in the dominant model, people with zero copies of the marker were 2 times more likely to respond to alefacept compared to subjects with either 1 or 2 copies of the marker.
26. When help gets there, you may get it whether you like it or not. There are numerous reports of aggressive, overbearing behavior by those rescuers who first arrived at disaster scenes. It's perhaps best described as "I'm here to rescue you - I'm in charge - do as I say - if you don't I'll shoot you". It appears that mid-level State functionaries and Red Cross personnel the latter without the "shoot you" aspect, of course ; were complained about most often. In one incident, a family who had prepared and survived quite well were ordered, not invited, to get onto a truck, with only the clothes on their backs. When they objected, they were threatened. They had pets, and wanted to know what would happen to them and they report that a uniformed man agency unknown ; began pointing his rifle at the pets with the words "I'll fix that". The husband then trained his own shotgun on the man and explained to him, in words of approximately one syllable, what was going to happen to him if he fired a shot. The whole "rescuer" group then left, threatening dire consequences for the family including threats to come back once they'd evacuated and torch their home ; . The family were able to make contact with a State Police patrol and report the incident, and are now determined that no matter how much pressure is applied, they will not evacuate. They've set up a "shuttle run" so that every few days, two of them go upstate to collect supplies for the rest of the family, who defend the homestead in the meantime and allergen.
Case. Reduced polymer content with respect to active ingredient, failure of the matrix material to form a nonerodable frame work, presence of swellable component i.e. Kollidon CL in Ludipress ; at relatively higher proportion may be considered for such deviation. In general, solubility of drug molecule itself crucially governs the rate and extent of diffusional release. For diffusion to occur, the first step is wetting of drug by water, followed by its dissolution so that the drug molecule is available in molecular form to diffuse out of the matrix. Hence, the net release rate observed is a cumulative effect of drug's solubility influenced by its structure, molecular weight and pka ; , polymer property hydrophilicity lipophilicity, molecular weight, tortuosity ; and the relative ratio of drug and polymer in the tablet. Kinetic analysis of Carnauba wax matrices yielded an aberrant value of release exponent n ; irrespective of physicochemical nature of the drug and no clear inference could be made regarding the kinetics of drug release from such matrices. The mechanism of drug release from wax matrices has been a matter of controversy since wax-systems tend to be crude and more heterogeneous than other classes of polymeric systems 34 ; . In some cases, it has been reported that the mechanism of release from wax matrices involves the leaching of drug by the eluting medium. Fluid enters through the cracks and pores of the matrix with diffusion of drug through the matrix being insignificant 35, 36 ; . Others have reported that release from a typical wax matrix is diffusion-controlled and is best described by Higuchi's t1 2 model 37, 38, 39, ; . Incorporation of HPMC-15 cps as the matrix forming agent, increased the value of n, indicating the tendency of drug release kinetics nearer to zero-order or case II transport rather than Fickian Case I ; mechanism. This phenomenon can generally be attributed to structural changes induced in the polymer by the penetrant 41 ; . HPMC-15 cps, being a class of hydrophilic matrix former swells in the presence of liquid solvent due to polymer relaxation and is characterized by the formation of a gel-like network surrounding the system. The mechanical property of the surface-hydrated gelatinous barrier plays an important role in overall drug release rate 4 ; . Although it is desirable for a controlled release device to deliver drug in zero-order kinetics, it is extremely difficult to attain such pattern as the kinetics of release is affected by the physico-chemical composition of surrounding medium and processing variables. The values of n had no definite relationship with.
Alefacept interferes with lymphocyte activation and aloxi.
Biogen's appeal and subsequent motion for a stay pending Biogen's appeal of the District Court decision to the Supreme Court on the merits. The compulsory license then became effective and permitted BTG-Israel to produce the vaccine in Israel upon receipt of regulatory approval and to export the vaccine to countries in which neither Biogen nor others have been granted a blocking patent. In March 1998 the Supreme Court granted Biogen the right to appeal the District Court's decision and determined that the appeal proceedings would be in the form of written submissions. BTG and Biogen concluded their respective submissions and replies at the end of 1999. Biogen's Israeli patent, however, expired in December 1999 and with it, the compulsory license, prior to any decision by the Supreme Court. The Supreme Court is expected to still rule on the issuance of the compulsory license because of the existence of the parallel infringement proceedings discussed below. In August 1992, Biogen sued BTG-Israel for allegedly infringing its Israeli patent which was the subject of the compulsory license ; by virtue of its preparation of BTG's BIO-HEP-B vaccine for use in clinical trials, and applied for an interlocutory injunction restraining BTG-Israel from continuing research and development activities and clinical trials. In June 1993, the District Court of Tel Aviv, Israel denied Biogen's application for an interlocutory injunction in connection with research and development and clinical trials, but enjoined BTG-Israel from commercial marketing of its BIO-HEP-B vaccine unless permitted by Biogen or its exclusive licensee, until a compulsory license is obtained, or until the patent expires or is revoked. With the grant of the compulsory license, Biogen and BTG agreed to suspend the infringement suit until a decision is rendered on Biogen's appeal to the Supreme Court of the grant of the compulsory license. Biogen has notified the District Court that if the compulsory license is upheld by the Supreme Court, it will withdraw the infringement suit. If, however, the infringement proceedings continue, there can be no assurance that the outcome of these proceedings will be favorable to BTG. Nevertheless, the expiry in December 1999 of the Biogen patent and in consequence thereof the compulsory licence, may reduce the significance of these proceedings. Also, an amendment to the Israel Patent Law, which came into effect in February 1998, provides that genuine experimental research in respect of a patented invention is not considered an infringement. As a result of the expiration of the patent, BTG cannot be precluded from manufacturing or selling BIO-HEP-B in Israel. See "Item 1. Business -- Products and Applications -- Hepatitis-B Vaccine." We have been advised by SciGen, our BIO-HEP-B licensee in certain countries in the Far East, that in April 1993 Biogen initiated suit against SciGen in Singapore asserting that SciGen's conduct of clinical trials in Singapore with respect to our hepatitis-B vaccine constitutes infringement of Biogen's patent rights in Singapore and claiming rights in the data obtained by SciGen through its clinical trials in Singapore and that an interlocutory hearing was held in September 1993. SciGen notified BTG that the application for the injunction was dismissed by the High Court in September 1994, but Biogen has not withdrawn its case against SciGen in Singapore. Biogen's Singapore patent rights are based on the registration of its corresponding U.K. patents, and the validity of patents in Singapore depends on the validity of the corresponding U.K. patents. Biogen's broad U.K. patent was invalidated by the U.K. Court of Appeals in October 1994. This decision was upheld by the House of Lords in October 1996, although Biogen had claims of a more limited scope allowed to the same patent. Additionally, three claims of a narrower U.K. patent were upheld. We believe that none of these claims will affect commercialization of our vaccine, although there can be no assurance of this. We are aware of certain other patents that have been granted or are pending and which, if granted, may prevent us from selling our vaccine in the United States, Europe and certain other countries. BTG's failure to obtain any needed license, or a determination that its vaccine infringes the patent rights of Biogen or others, would substantially limit, if not prohibit, the commercialization of the BIO-HEP-B vaccine in those countries in which Biogen or others have a patent until such patent is revoked or expires. Our ability to secure any necessary licenses or sublicenses to these patents or applications cannot be predicted. Additionally, in 1984 an Israeli patent application of Biogen which relates to expression vectors was accepted; BTG is opposing the grant of this patent. There can be no assurance that BTG will be successful in its opposition to the grant of this patent. If BTG is unsuccessful in its 35 and alefacept.
SYNTHELABO GROUP CONSOLIDATED STATEMENT OF INCOME Six Months Ended June 30, 1999 in millions of euro, except share and per-share amount ; Net sales note B.22 ; . Cost of goods sold . Gross profit Research and development expenses . Selling and general expenses Other operating income expense ; , net note A.4.3 ; . Operating profit note B.22 ; . Intangibles amortization and impairment . Financial income expense ; , net note A.4.5 ; . Profit before tax and exceptional items . Exceptional items note B.18 ; . Income taxes note B.19 ; . Net income before income from equity investees, goodwill amortization and minority interests note A.4.7 ; . Income from equity investees, net note B.3 ; . Goodwill amortization . Net income before minority interests . Minority interests . Net income . 995 261 ; 734 152 ; 373 ; 29 ; 180 8 ; 3 ; 169 2 ; 55 ; 112 1 2 ; 111 2 ; 109 and amen
[Chpt 19] Then Pilate took Jesus and scourged him. And the soldiers wound a crown of thorns and put it on his head. And they did on him a purple garment, and said: hail king of the Jewes: and they smote him on the face. Pilate went forth again and said unto them: behold I bring him forth to you, that ye may know, that I find no fault in him. Then came Jesus forth wearing a crown of thorns and a robe of purple. And Pilate said unto them: behold the man. When the high Priests and ministers saw him, they cried saying: crucify him, crucify him. Pilate said unto them. Take ye him and crucify him: for I find no cause in him. The Jewes answered him. We have a law, and by our law he ought to die: because he made himself the son of God. When Pilate heard that saying he was the more afraid, and went again into the judgement hall, and said unto Jesus: whence art thou? But Jesus gave him none answer. Then said Pilate unto him: Speakest thou not unto me? Knowest thou not that I have power to crucify thee, and have power to loose thee? Jesus answered: Thou couldest have no power at all against me, except it were given thee from above. Therefore he that delivered me unto thee, is more in sin. And from thenceforth sought Pilate means to loose him: but the Jewes cried saying: if thou let him go thou art not Casars friend. For whosoever maketh himself a king is against Caesar. When Pilate heard that saying, he brought Jesus forth, and sat down to give sentence, in a place called the pavement: but in the Hebrew tongue, Gabbatha. It was the Saboth even which falleth in the * ester feast, and about the sixth hour. And he said unto the Jewes: behold your king. They.
Major interactions adalimumab , aptivus , ardeparin , arixtra , arixtra 10 mg dose , arixtra 5 mg dose , arixtra 5 mg dose , attenuvax , bcg , bexxar dosimetric , bexxar i 131 dosimetric , bexxar i 131 therapeutic , bexxartherapeutic , clexane , clexane forte , clopine , clozapine , clozapine synthon , clozaril , dalteparin , danaparoid , dasatinib , denzapine , drotrecogin , drotrecogin alfa , dryvax , enbrel , enbrel sureclick , enoxaparin , etanercept , fazaclo , flumist , fondaparinux , fragmin , humira , humira pen , humira pen crohn's disease starter package , ibritumomab , in-111 zevalin , infliximab , influenza virus vaccine, live, trivalent , innohep , iodine i 131 tositumomab , lovenox , lovenox hp , measles virus vaccine , meruvax ii , mumps virus vaccine , mumpsvax , natalizumab , normiflo , opv , orgaran , orimune , poliovirus vaccine, live, trivalent , quadramet , remicade , rotateq , rotavirus vaccine , rubella virus vaccine , sabin , samarium sm 153 lexidronam , smallpox vaccine , sprycel , thalidomide , thalomid , theracys , tice bcg vaccine , tinzaparin , tipranavir , topv , tositumomab , typhoid vaccine, live , tysabri , varicella virus vaccine , varivax , vivotif berna , xigris , y-90 zevalin , yellow fever vaccine , yf-vax , zaponex , zostavax , zoster vaccine live , moderate interactions acthib , acthib obsolete ; , acular , acular ls , acular pf , afluria , alatrofloxacin , alefacept , alemtuzumab , amevive , anafranil , anakinra , anthrax vaccine adsorbed , aplisol , aplitest , avelox , avelox , azasan , azathioprine , biothrax , bromfenac ophthalmic , campath , candida albicans extract , candida skin test , candin , celexa , cholera vaccine , cinobac , cinoxacin , cipro , cipro cystitis pack , cipro , cipro xr , ciprofloxacin , ciprofloxacin extended release , citalopram , clomipramine , coccidioidin skin test , cytovene , dexfenfluramine , diclofenac ophthalmic , diclofenac topical , efalizumab , elmiron , engerix-b , engerix-b pediatric , enoxacin , escitalopram , factive , fenfluramine , filgrastim , flector patch , floxin , floxin , fluarix , flulaval , fluogen , fluoxetine , fluoxetine extended release , flurbiprofen ophthalmic , flushield , flushield obsolete ; , fluvirin , fluvirin preservative-free , fluvoxamine , fluzone , fluzone pfs , fluzone preservative-free , fluzone preservative-free pediatric , fluzone sv , fluzone wv , g-csf , ganciclovir , gardasil , gatifloxacin , gemifloxacin , gm-csf , grepafloxacin , haemophilus b conjugate hboc ; vaccine , haemophilus b conjugate prp-omp ; vaccine , haemophilus b conjugate prp-t ; vaccine , haemophilus b conjugate vaccine obsolete ; , haemophilus b diphtheria conjugate vaccine , haemophilus b neisseria conjugate vaccine , haemophilus b tetanus conjugate vaccine , havrix , havrix obsolete ; , havrix pediatric , havrix pediatric obsolete ; , hemin , hepatitis a adult vaccine , hepatitis a pediatric vaccine , hepatitis a vaccine obsolete ; , hepatitis b vaccine , hibtiter , hibtiter obsolete ; , histolyn-cyl , histoplasmin , histoplasmin diluted , hpv , human papillomavirus vaccine , hycamtin , iloprost , imovax rabies , imovax rabies obsolete ; , imovax rabies obsolete ; , imuran , influenza virus vaccine, inactivated , ipol , ipv , japanese encephalitis virus vaccine , je-vax , kepivance , ketorolac ophthalmic , kineret , leukine , levaquin , levaquin leva-pak , levofloxacin , lexapro , liquid pedvaxhib , lomefloxacin , luvox , lyme disease vaccine , lymerix , maxaquin , menactra , meningococcal conjugate vaccine , meningococcal polysaccharide vaccine , menomune a c y w-135 , meridia , mixed respiratory vaccine , mono-vacc test ; , moxifloxacin , msta mumps skin test antigen , multitest cmi , mumps skin test antigen , nalidixic acid , neggram , nepafenac ophthalmic , neulasta , neupogen , nevanac , norfloxacin , noroxin , ocufen , ofloxacin , omnihib , palifermin , panhematin , paroxetine , paroxetine extended release , paroxetine mesylate , paxil , paxil cr , pedvax hib , pegfilgrastim , penetrex , pentosan polysulfate sodium , pexeva , plague vaccine , pneumococcal 23-valent vaccine , pneumococcal 23-valent vaccine obsolete ; , pneumococcal 7-valent vaccine , pneumovax 23 , pneumovax 23 obsolete ; , pnu-imune 23 obsolete ; , poliovirus vaccine, inactivated , pondimin , prevnar , prohibit , proquin xr , prozac , prozac weekly , rabavert , rabavert obsolete ; , rabies vaccine obsolete ; , rabies vaccine, human diploid cell , rabies vaccine, purified chick embryo cell , rapiflux , raptiva , raxar , recombivax hb , recombivax hb adult , recombivax hb dialysis formulation , recombivax hb pediatric adolescent , redux , remodulin , sarafem , sargramostim , sclavo test-ppd , sertraline , sibutramine , skin test antigens, multiple , solaraze , sparfloxacin , spherulin , spl , staphage lysate spl ; 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TABLE 1. Basic abbreviation list for currently used biologicals in trials and publications in rheumatology Abbreviation code ABC ADM ALC ANR EFZ ETC INX ONC RIX TOZ Biological generic Abatacept Adalimumab Alefacept Anakinra Efalizumab Etanercept Infliximab Onercept Rituximab Tocilizumab and aleve.
Alefacept is a new biological drug for treating patients with moderate-to-severe psoriasis, which is currently treated with UV phototherapy, topical agents, systematic drugs or climate therapy. A large international multicentre phase III trial encompassing more than 1, 000 patients showed significant improvement of psoriasis following either intravenous or intramuscular injection of alefacept relative to the placebo group. Alefacept reduces the number of circulating CD4 + T-lymphocytes, but no correlation was found between a low CD4 + T-cell count and infections. Quality of life, which is lowered in psoriasis patients, improves upon treatment with alefacept. In view of its efficacy and apparently good side effect profile, alefacept has the potential to become part of psoriasis treatment. A barrier to its more widespread use could be the price and amikacin
Alefacept is not fda approved for combination therapies, and will be reimbursed only when used as mono-therapy or when tapering of a previous therapy during the initiation of alefacept treatment is documented in the medical record.
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