Bilberry extract improves your eyesight.
Willard A. Bernbaum Cystic Fibrosis Research Center, Department of Pediatrics, Rainbow Babies and Children's Hospital, and Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Flavonoids are a class of low-molecular-weight phenolic compounds that are widely distributed in the plant kingdom. Over 6000 naturally occurring flavonoids have been described, and many of them are common in higher plants Harborne & Williams 2000 ; . These compounds frequently serve as pigments in plants, but are also involved in many biological interactions. Flavonoids are built upon a C6-C3-C6 flavone skeleton in which the three-carbon bridge between the phenyl groups is commonly cyclized with oxygen. Based on the degree of unsaturation and oxidation of the three-carbon segment, flavonoids are divided in several classes Fig.1A ; . Most flavonoids reported in the literature are glycosides of a relatively small number of flavonoid aglycons, which are generally water-soluble and accumulate in the vacuoles of plant cells Bohm 1998, Seigler 1998 ; . A significant role of flavonoids that has been under very active research recently, is their possible beneficial influence on human health. Flavonoids have been found to own potent antioxidant and free radical scavenging activities in vitro. There is growing evidence from human consumption studies supporting a protective role of flavonoids in cardiovascular diseases and cancer. Many flavonoids have been found to possess antiviral, antibacterial, antifungal or anti-allergenic properties. However, because of the wide variety of different flavonoids, their possible interactions with other substances, and the complexity of their metabolism in the human system, more research in this area is still needed Hertog et al. 1995, Hollman et al. 1996, Peterson & Dwyer 1988, Ross & Kasum 2002 ; . Blueberries, which are a rich source of anthocyanins, have been found to be beneficial for health Kalt & Dufour 1997, Smith et al. 2000 ; . The antioxidant capacity of blueberries has been analyzed in several studies Heinonen et al. 1998, Prior et al. 1998, Kalt et al. 1999, 2000, Khknen et al. 2001, Moyer et al. 2002 ; . Also, the anticancer activity of the Vaccinium species Bomser et al. 1996, Katsube et al. 2003 ; and the antimicrobial properties of berry phenolics, including those from the Vaccinium species, Rauha et al. 2000, Puupponen-Pimi et al. 2001 ; have been studied in vitro. Cranberry V. macrocarpon, V. oxycoccos ; proanthocyanidins have been found to prevent urinary tract infections Howell et al. 1998, Kontiokari et al. 2001 ; . A study of Youdim et al. 2000 ; showed the beneficial effects of blueberries on brain functions related to ageing in vivo. Bilberry fruits and leaves were used in folk medicine in Europe already in the Middle Ages Morazzoni & Bombardelli 1996 ; . In the US, bilberry has been among the most significant herbs for sale during the recent years Blumenthal 1999, 2001.
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Failure. Heart J 1999; 138: 285-90. Maisel A. B-type natriuretic peptide levels: a potential novel "white count" for congestive heart failure. J Card Fail 2001; 7: 183-93. Alderman EL, Fisher LD, Litwin P, et al. Results of coronary artery surgery in patients with poor left ventricular function CASS ; . Circulation 1983; 68: 785-95. Mueller C, Scholer A, Laule-Kilian K, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 2004; 350: 647-54. Wang TJ, Larson MG, Levy D, et al. Impact of obesity on plasma natriuretic peptide levels. Circulation 2004; 109: 594-600. Mehra MR, Uber PA, Park MH, et al. Obesity and suppressed Btype natriuretic peptide levels in heart failure. J Coll Cardiol 2004; 43: 1590-5. Wright SP, Doughty RN, Pearl A, et al. Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: a randomized, controlled trial. J Coll Cardiol 2003; 42: 1793-800. Gheorghiade M, Bonow RO. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation 1998; 97: 282-9. Masoudi FA, Havranek EP, Smith G, et al. Gender, age, and heart failure with preserved left ventricular systolic function. J Coll Cardiol 2003; 41: 217-23. Smith GL, Masoudi FA, Vaccarino V, Radford MJ, Krumholz HM. Outcomes in heart failure patients with preserved ejection fraction: mortality, readmission, and functional decline. J Coll Cardiol 2003; 41: 1510-8. Eagle KA, Guyton RA, Davidoff R, et al. ACC AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology American Heart Association Task Force on Practice Guidelines Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery ; . Available at: : acc clinical guidelines cabg cabg . Access date 6 30 05. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Coll Cardiol 2002; 39: 1151-8. Cheitlin MD, Armstrong WF, Aurigemma GP, et al. ACC AHA ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology American Heart Association Task Force on Practice Guidelines ACC AHA ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography ; . J Soc Echocardiogr 2003; 16: 1091-110. Klocke FJ, Baird MG, Lorell BH, et al. ACC AHA ASNC guidelines for the clinical use of cardiac radionuclide imaging: executive summary: a report of the American College of Cardiology American Heart Association Task Force on Practice Guidelines ACC AHA ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging ; . J Coll Cardiol 2003; 42: 1318-33. Fox KF, Cowie MR, Wood DA, et al. Coronary artery disease as the cause of incident heart failure in the population. Eur Heart J 2001; 22: 228-36. Lie JT. Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease. Ann Intern Med 1988; 109: 525-8. Chow LC, Dittrich HC, Shabetai R. Endomyocardial biopsy in patients with unexplained congestive heart failure. Ann Intern.
An experimental ED50 value significantly different from the predicted additive ED50 value P 0.05.
Also, taking bilberry with other herbs that also lower blood sugar may result in hypoglycemia low blood sugar and bioflavonoids
A copy of this report will be sent to the Medical Council of New Zealand and the Royal New Zealand College of General Practitioners. A copy of this report, with identifying details removed, will be sent to Women's Health Action and the Federation of Women's Health Councils Aotearoa, and placed on the Health and Disability Commissioner website, hdc .nz, for educational purposes.
The research and development costs connected with the safinamide project are expensed as incurred and entirely refunded by Merck Serono. The research and development costs connected with the other com and biperiden
METHODS hyperlymphocytosis and were hematologic stable no the upper majority positivity. half-life for patients studies a splenic and observed in two with lgG were bone lambda observed remained recurrent and data during respiratory of blood neuare a
Source Naturals continued ; Silymarin Plus 30 tab ; Silymarin Plus 60 tab ; Smilax Liquid Extract Sarsaparilla ; 1 oz ; Smilax Liquid Extract Sarsaparilla ; 2 oz ; Sodium Ascorbate Buffered C Crystals 16 oz ; Sodium Ascorbate Buffered C Crystals 8 oz ; Spirulina Multiple, vegetarian 100 tab ; Spirulina Powder 4 oz ; Spirulina Powder 9 oz ; Spirulina, 500 mg 100 tab ; Spirulina, 500 mg 200 tab ; Spirulina, 500 mg 500 tab ; St. John's Wort NutraSpray, 75 mg 2 oz ; St. John's Wort Standardized Extract, 300 mg 120 cap ; St. John's Wort Standardized Extract, 300 mg 120 tab ; St. John's Wort Standardized Extract, 300 mg 240 cap ; St. John's Wort Standardized Extract, 300 mg 240 tab ; St. John's Wort Standardized Extract, 300 mg 60 cap ; St. John's Wort Standardized Extract, 300 mg 60 tab ; St. John's Wort Standardized Extract, 450 mg 180 tab ; St. John's Wort Standardized Extract, 450 mg 45 tab ; St. John's Wort Standardized Extract, 450 mg 90 tab ; Sugar Ban Gymnema Sylvestre Complex 30 tab ; Sugar Ban Gymnema Sylvestre Complex 75 tab ; Suma from Brazil, 500 mg 24 tab ; Suma from Brazil, 500 mg 50 tab ; Super Carrot Acidophilus, Dairy-Free 100 cap ; Super Carrot Acidophilus, Dairy-Free 50 cap ; Super Sprouts Antioxidant Catalyst, 900 mg 120 tab ; Super Sprouts Antioxidant Catalyst, 900 mg 60 tab ; Super Sprouts Plus Antioxidant Catalyst with Cofactors, 900 mg 120 tab ; Super Sprouts Plus Antioxidant Catalyst with Cofactors, 900 mg 60 tab ; Swedish Flower Pollen Extract 45 tab ; Swedish Flower Pollen Extract 90 tab ; Taurine Powder 100 grams ; Tocotrienol Antixodant Complex with Vit. E 30 cap ; Tocotrienol Antixodant Complex with Vit. E 60 cap ; trans-Ferulic Acid, 250 mg 30 tab ; trans-Ferulic Acid, 250 mg 60 tab ; Triathlete Maximum Endurance Formula 100 tab ; Triathlete Maximum Endurance Formula 40 tab ; Trimethylglycine TMG ; , 750 mg 120 tab ; Trimethylglycine TMG ; , 750 mg 240 tab ; 5.25 9.90 4.65 SN0035 SN0036 SN0718 SN0730 SN0443 SN0442 SN0001 SN0635 SN0636 SN0637 SN0638 SN0639 SN1005 SN0901 SN0898 SN0902 SN0899 SN0900 SN0897 SN1177 SN1175 SN1176 SN0788 SN0789 SN0250 SN0251 SN0615 SN0614 SN0977 SN0976 SN0979 SN0978 SN1296 SN1297 SN0166 SN0405 SN0406 SN0804 SN0805 SN0025 SN0024 SN0877 SN0878 Source Naturals continued ; Trimethylglycine TMG ; , 750 mg 60 tab ; Turmeric Extract, 95% Curcumin 100 tab ; Turmeric Extract, 95% Curcumin 50 tab ; Ultimate Ascorbate C 100 tab ; Ultimate Ascorbate C 50 tab ; Ultimate Ascorbate C Powder 16 oz ; Ultimate Ascorbate C Powder 4 oz ; Ultimate Ascorbate C Powder 8 oz ; Ultimate Ester C with Minerals 100 tab ; Ultimate Ester C with Minerals 50 tab ; Ultra Chromium GTF, 200 mcg 120 tab ; Ultra Chromium GTF, 200 mcg 60 tab ; ` Ultra Chromium Picolinate, 500 mcg 120 tab ; Ultra Chromium Picolinate, 500 mcg 60 tab ; Ultra Colloidal Gold, 10 ppm 1 oz ; Ultra Colloidal Gold, 10 ppm 2 oz ; Ultra Colloidal Gold, 10 ppm 4 oz ; Ultra Colloidal Silver Mouth and Throat Spray 1 oz ; Ultra Colloidal Silver Mouth and Throat Spray 2 oz ; Ultra Colloidal Silver Nasal Spray 1 oz ; Ultra Colloidal Silver Nasal Spray 2 oz ; Ultra Colloidal Silver Salve 0.5 oz ; Ultra Colloidal Silver Salve 1 oz ; Ultra Colloidal Silver Salve 2 oz ; Ultra Colloidal Silver, 10 ppm 2 oz ; Ultra Colloidal Silver, 10 ppm 4 oz ; Ultra Colloidal Silver, 10 ppm 8 oz ; Ultra Inosine Endurance Complex 24 tab ; Ultra Inosine Endurance Complex 50 tab ; Ultra Joint Response 180 tab ; Ultra Joint Response 45 tab ; Ultra Joint Response 90 tab ; Ultra Multiple 42 tab ; Ultra Multiple 90 tab ; Ultra Potassium, 99 mg 100 tab ; Ultra Potassium, 99 mg 200 tab ; Ultra-Cal Night Formula 120 tab ; Ultra-Cal Night Formula 240 tab ; Ultra-Cal Night Formula 60 tab ; Ultra-Mag High Efficiency Magnesium 120 tab ; Ultra-Mag High Efficiency Magnesium 240 tab ; Ultra-Mag High Efficiency Magnesium 60 tab ; Urban Air Defense Antioxidant 30 tab ; Urban Air Defense Antioxidant 60 tab ; Vincamine, 30 mg 30 tab ; Vincamine, 30 mg 60 tab ; Vinpocetine, 10 mg 120 tab ; Vinpocetine, 10 mg 60 tab ; Visual Eyes with Bilberry Extract & Lutein formerly Vital Eyes ; 120 tab ; Visual Eyes with Bilberry Extract & Lutein formerly Vital Eyes ; 30 tab ; Visual Eyes with Bilberry Extract & Lutein formerly Vital Eyes ; 60 tab ; Visual Eyes with Bilberry Extract & Lutein formerly Vital Eyes ; 90 tab ; Vitamin A and D, 10, 000 IU 400 IU 100 tab ; 6.30 14.39 7.50 SN0876 SN0089 SN0088 SN0832 SN0831 SN0092 SN0090 SN0091 SN0469 SN0468 SN0364 SN0363 SN0516 SN0515 SN0256 SN0257 SN0258 SN0590 SN0591 SN0017 SN0018 SN0350 SN0351 SN0352 SN0220 SN0221 SN0319 SN0661 SN0662 SN1221 SN1219 SN1220 SN0002 SN0003 SN0235 SN0236 SN1063 SN1064 SN1062 SN0803 SN0033 SN0802 SN0736 SN0737 SN1159 SN1160 SN1399 SN1398 SN0097 SN0386 SN0387 SN0388 SN0826 and bisacodyl.
Bilberry herbal extract
No yes report abuse rated bilberry vaccinium myrtillus ; for multiple sclerosis - relapsing-remitting rrms ; product posted 02 10 2006 over 2 years ago ; 0 of 0 people found the following helpful: perceived effectiveness 10 1 0 based on scale of 0 to lack of side effects tolerability ; 10 1 0 based on scale of 0 to ease of use 10 1 0 based on scale of 0 to would you recommend.
From smoke that are harmful while at the same time 4 medicinal value of TtIC." 264. d. Dr. Abrams reiterated that his research and bleomycin.
Household member. Dependent variables included in the model were the number of adults in the household as well as the age, gender, education, race, and smoking status of the self-respondent. Table 2 shows the distributions of various factors related to the household and self-respondents. Long-term quitters had the lowest discrepancy rates. The highest rates were found for those who were black, Hispanic, and Asian; those with annual household incomes above , 000; persons aged 25-34 years; and recent quitters. These factors remained statistically significant even when we.
Under the Blood Plasma ConcentraPh.D., AKwETE .Aijxx, M.S., AL859 and boniva.
Sympathetically Maintained Pain Syndrome, is rejected by Stanton-Hicks et al.8 as a variable phenomenon that should be seen as a symptom and is associated with various abnormalities, including CRPS-I. In 1994 the IASP held a consensus conference7 at which the term Complex Regional Pain Syndrome CRPS-I ; was introduced along with corresponding diagnostic criteria see table 3 ; . This classification is descriptive in nature, and not based on pathophysiology or scientific findings. Rather, it is the result of consensus based on expert opinion8. Pain is the sine qua non for this diagnosis. This classification of CRPS-I has been criticised both inside and outside the IASP. Galer et al. examined 18 CRPS-I patients and found it to be insufficiently specific59. Both Galer et al.59 and Harden et al.60 contend that the criteria need to be validated by empirical research. It seems that the IASP criteria have to date been used in only 15% of all recent research in this field61, 62. Bruehl et al. conducted a study on 117 patients with CRPS-I and proposed a change to the criteria, rendering them more specific table 4 ; 58. Unfortunately, this also results in a loss of sensitivity, as Van de Vusse et al. have confirmed63. The changes proposed by Bruehl et al.58 have not so far been accepted or adopted by the IASP. However, these 'researchdiagnostic criteria' put forward by Bruehl et al. might allow CRPS-I to be more clearly distinguished from other forms of neuropathic pain. Baron et al.64 produced a commentary suggesting another change to these diagnostic criteria see appendix 2 ; , but this has not yet been ratified either. The objections against the IASP criteria are the small numbers of patients participating in the various trials and the requirement for pain and or sensitivity disorders to be present. But the supporters of the criteria see the latter aspect as one of its advantages. No laboratory tests are needed in order to establish the diagnosis of CRPS-I on the basis of the aforementioned criteria, and there is also no need to ascertain whether the symptoms improve in response to nerve blockade sympathetic blockade ; 59. The use of these criteria allows practitioners to diagnose CRPS-I by means of anamnesis and physical examination alone60. See also section 1.3 on additional diagnosis. The criteria drawn up by Veldman et al.1 table 5 ; , widely used in the Netherlands, are also based on anamnesis and physical examination. The difference between these criteria and the IASP criteria is that pain is not a requirement per se. Veldman et al.1 also reported that no causal noxa could be found in about 10% of 829 patients with RSD spontaneous RSD ; . They therefore concluded that sensitivity disorders were not always a required feature.
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That instinct which made her shrink from her mother's presence was not without its justification; the dark powers which circled her existence had not vainly forced their influence upon her. Her first impulse was to flee from the house; the air breathed pestilence and death, death of the soul. Looking about her in the anguish of conflicting thoughts, her eyes fell upon the pages she had written. These now came before her as a proof of contagion which had seized upon her own nature; she tore the letter hastily into fragments, and, striking fire with a match, consumed them in the grate. As she watched the sparks go out, there came a rustling of dresses past her door. She flung herself upon her knees and sought refuge in wild, wordless prayer. A fortnight after this Maud went late in the evening to the room where she knew her father was sitting alone. Paul Enderby looked up from his papers in surprise; it was some time since Maud had sought private conversation with him. As he met her pale, resolute face, he knew that she had a serious purpose in thus visiting him, and his look changed to one of nervous anticipation. "Do I disturb you and bortezomib.
Area of lichen heath with sheeps fescue, wavy hair-grass Deschampsia flexuosa and Rhacomitrium lanuginosum. This is of particular interest as it forms the largest example of this habitat in the Lake District where it is very rare and only found from two other localities: the summits of Skiddaw and Kirk Fell. To the north of Scafell Pike are a series of species rich high altitude gills which lead down to Lingmell Beck, of which Piers Gill provides the classic example of this type in Cumbria. The gill supports a range of tall herb ledge communities with roseroot Sedum rosea, mountain sorrel Oxyria digyna, northern bedstraw, alpine ladys mantle, wild angelica and alpine meadow-rue. Also present are starry, purple and mossy saxifrages Saxifraga stellaris, S. oppositifolia and S. hypnoides and in places banks of mountain saxifrage S. aizoides grow in profusion. Other ledges are dominated by great wood-rush Luzula sylvatica and bilberry with a wide range of ferns including lemon-scented fern Oreopteris limbosperma, beech fern Phegopteris connectilis, oak fern Gymnocarpium dryopteris, scaly male-fern and broad buckler fern. The species composition of the neighbouring gills of Skew and Greta is similar but in Skew Gill there is a greater abundance of purple saxifrage. In contrast, Ruddy Gill to the north-east of Great End has a more lowland character and as a result supports a different range of herbs and is more wooded. Species include devils-bit scabious Succisa pratensis, stone bramble Rubus saxatilis, marsh hawks-beard Crepis paludosa and common valerian Valeriana officinalis. Herb rich ledges also occur on several of the crags within the site and support a similarly diverse range of species to those associated with the gills. Cam Spout, Great End, Lingmell and Horn Crags are particularly rich and support roseroot, bladder campion Silene maritima, golden-rod Solidago virgurea, great woodrush and in places abundant heather Calluna vulgaris. In addition uncommon species such as dwarf juniper Juniperus communis spp. nana, alpine cinquefoil Potentilla crantzii, glaucous meadow-grass Poa glauca, alpine saw-wort Saussurea alpina and bearberry Arctosaphylos uva-ursi occur. Below the summit plateau and crags the slopes are a mosaic of scree, grassland and bilberry heath. The grasslands are generally dominated by mat-grass Nardus stricta with sheeps fescue, tormentil Potentilla erecta, heath bed-straw, and green-ribbed sedge Carex binervis. The scree slopes however, support few higher plants, but in places as on the south-west face of Scafell abundant Rhacomitrium lanuginosum with patches of grass heath are present. Lying to the north of Great End are Sprinkling and Styhead Tarns, which are good examples of upland nutrient poor tarns. In both cases marginal aquatics include bulbous rush Juncus bulbosus, intermediate water-starwort Callitriche hamulata, quillwort Isoetes lacustris, shoreweed Littorella uniflora and floating bur-reed Sparganium angustifolium. Awlwort Subularia aquatica a locally rare species occurs in both tarns, but water lobellia Lobellia dortmanna is only found in Styhead Tarn. Between the two tarns on Seathwaite Fell lies an extensive area of mat-grass with flushes and small pools. This area supports one of the largest known populations of the nationally scarce Mountain Ringlet Erebia epiphron in Cumbria, whilst the summit boulder field of Scafell is the only known English locality for the boreo-British ground beetle Nebria nivalis. The site also supports breeding peregrine, raven, ring ouzel and wheatear and bilberry.
Benefits of bilberry blueberry
The bilberry shrub bears small white and pink flowers which turn into dark purple berries and bosentan.
Outgrowth, we established TGW cell lines that stably expressed human wild-type Dok-4 [TGW Dok-4 ; ] Fig. 2Aa ; . Overexpression of Dok-4 markedly enhanced neurite outgrowth by TGW cells after GDNF stimulation Fig. 2Ab, B ; . The degree of neurite outgrowth was quantified, and results confirmed using three clones. The Ras ERK, PI 3 ; K AKT, and Rac JNK-dependent pathways have been implicated in GDNFmediated cell proliferation, neurite outgrowth, cell migration and or cytoskeleton remodeling Ichihara et al., 2004; Kodama et al., 2005 ; . Using selective kinase inhibitors, we examined whether the blockade of each of these pathways could inhibit GDNF-induced neurite outgrowth Fig. 2Ab, B ; . Blockade of.
Characterization of the nirK gene encoding the respiratory, Cucontaining nitrite reductase of Bradyrhizobium japonicum. Biochim Biophys Acta 1521, 130134 and botox.
ADLER into phone ; On our way, Marge. Adler hangs up the phone. ADLER Gettin' antsy, Red. You scheduled it. Adler hangs up, grabs Red's tie and coat from a brass rung on the wall and hands them over. Red puts down the telex, stares at Sally and reluctantly attempts to make himself presentable. SALLY The idea is that an understanding of the particular behavioral case histories should, in parole situations, help the subject to avoid habitual traps and, in penal escape situations could, conversely, identify those self-same traps as an aide to apprehension. CONTINUED and bioflavonoids.
Maryland Department of Health & Mental Hygiene DHMH ; Center for Immunization VFC Room 321M 201 W. Preston Street Baltimore, MD 21201 Phone: 410-767-6030 Fax: 410-333-5893 Email: Mackdan dhmh ate.md Visit Us On Line: edcp Serving Maryland's Children Since 1994 and bronchial.
Pierre Boutouyrie, Michel Azizi, Hopital Europeen Georges Pompidou, Paris, France; Mohsen Agharazii, INSERM EMI 0107, Paris, France; Alvine Bissery, Hopital Europeen Georges Pompidou, Paris, France; Francis Verbeke, INSERM EMI 0107, Paris, France; Francois Alhenc-Gelas, INSERM U367, Paris, France; Stephane Laurent, INSERM EMI 0107, Paris, France; Xavier Jeunemaitre, Hopital Europeen Georges Pompidou, Paris, France Objectives : A loss-of-function polymorphism Arg53His, allele frequency: 0.04 ; of the human kallikrein gene hKLK1 ; alters KLK enzymatic activity and is associated with a 50% reduction in urinary kallikrein activity UKLKa ; in R53H heterozygotes. Mice lacking tissue KLK gene have endothelial dysfunction with reduced flow-induced vasodilatation. We investigated whether endothelial function EF ; and arterial properties were altered in R53H heterozygotes compared to wild-type R53R homozygotes . Design and methods : 30 R53R and 10 R53H normotensive Caucasian subjects were randomly assigned in a crossover study to 2 contrasted UKLKa modulating diets of low NaCl 20 mmol d ; and high KCl 140 mmol d ; intake LNHK ; and high NaCl 250 mmol d ; and low KCl 50 mmol d ; intake HNLK ; administered during 1 week. Diameter D ; and shear stress SS ; of the brachial artery were measured before B ; , during 5 min hand ischemia HI ; , and during reactive hyperhemia HH ; and after 150 g of TNT sublingual post-TNT ; using RF ; -based echotracking techniques Walltrack system ; blinded to the diet and genotype. Results : UKLKa was lower in R53H than R53R subjects, especially during LNHK median: 20017 vs 51515 U 24h, respectively, p 0.01 ; . R53H subjects had significantly smaller D and increased SS in all experimental conditions B, HI, HH, post-TNT; * p 0.05, R53R vs. R53H ; . HNLK diet tended to accentuate differences between genotypes. Changes in diameter during hyperhemia did not differ between genotypes. However, when DD % ; was normalized to changes in SS EF index ; , EFi was significantly altered under HNLK diet. Conclusion : Besides a 50% reduction in UKLKa, the R53H subjects have an inward eutrophic remodeling of the brachial artery, together with a chronic increase in SS. But R53H have no modification in EF, despite chronic increase in SS. HNLK diet per se altered significantly EF for both genotypes by comparison to LNHK.
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